1-Arvind G Jangid.pmd
نویسندگان
چکیده
A rapid, simple and selective method for estimation of erythromycin ethylsuccinate in human plasma was validated using imipramine as internal standard. The analyte and internal standard were extracted from plasma using simple solid phase extraction. The compound were separated on a reverse-phase column with an isocratic mobile phase consisting of 0.1% formic acid in water and acetonitrile (20:80, v/v) and detected by tandem mass spectrometry in positive ion mode. The ion transition recorded in multiple reaction monitoring mode were m/z 862.5 → 286.2 for erythromycin ethylsuccinate and m/z 281.2 → 208.1 for internal standard. Linearity in plasma was observed over the concentration range 10 – 1500 ng/mL for erythromycin ethylsuccinate. The method was validated to be linear, precise and accurate. The lower limit of quantification of erythromycin ethylsuccinate was 10.0 ng/mL. The mean recovery for erythromycin ethylsuccinate was 62.7%. The coefficient of variation of the assay was less than 7.0 % and accuracy of 91.4% to 97.1%. The validated method was applied to pharmacokinetic study of erythromycin oral suspension 250 mg/mL (as ethylsuccinate) in healthy human volunteers.
منابع مشابه
Near-Optimal Expanding Generating Sets for Solvable Permutation Groups
Let G = 〈S〉 be a solvable permutation group of the symmetric group Sn given as input by the generating set S. We give a deterministic polynomial-time algorithm that computes an expanding generating set of size Õ(n) for G. More precisely, the algorithm computes a subset T ⊂ G of size Õ(n)(1/λ) such that the undirected Cayley graph Cay(G, T ) is a λ-spectral expander (the Õ notation suppresses lo...
متن کاملCharacterization of ModL using Prime Modulus
The complexity class ModL was defined by Arvind and Vijayaraghavan in [AV04] (more precisely in [Vij08, Definition 1.4.1][AV, Definition 3.1]). In this paper, under the assumption that NL = UL, we show that for every language L ∈ ModL there exists a function f ∈ #L and a function g ∈ FL such that on any input string x, we have • g(x) = 0 for some prime p, and, • if x ∈ L then f(x) ≡ 1(mod p), •...
متن کاملNuclear factor B signaling regulates neuronal morphology and cocaine reward
Scott J. Russo,1 Matthew B. Wilkinson,1* Michelle S. Mazei-Robison,1* David M. Dietz,1 Ian Maze,1 Vaishnav Krishnan,2 William Renthal,2 Ami Graham,2 Shari G. Birnbaum,2 Thomas A. Green,2 Bruce Robison,2 Alan Lesselyong,2 Linda I. Perrotti,2 Carlos A. Bolaños,2 Arvind Kumar,2 Michael S. Clark,3 John F. Neumaier,3 Rachael L. Neve,4 Asha L. Bhakar,5 Philip A. Barker,5 and Eric J. Nestler1 1Fishber...
متن کاملMcgraw and Et Al. Sisal: Streams and Iteration in a Single Assignment Language| Language Reference Manual Version 1.2. Technical Report M-146
[16] J. M. Monti. Interprocessor communication supports for a multiprocessor data BLOCKINow machine. Master's thesis, [2] Arvind and R.S. Nikhil. Executing a program on the MIT tagged-token data BLOCKINow architecture. [3] John Backus. Can programming be liberated from the von Neumann style? A functional style and its algebra of programs.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2012